Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation

BACKGROUND: Tolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate the exact mechanisms and efficient treatment. Microglial activation and neuroinflammation in the spinal cord are thought to play pivotal roles on the genesis and maintaining...

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Опубликовано в: :J Neuroinflammation
Главные авторы: Pan, Yinbing, Sun, Xiaodi, Jiang, Lai, Hu, Liang, Kong, Hong, Han, Yuan, Qian, Cheng, Song, Chao, Qian, Yanning, Liu, Wentao
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114746/
https://ncbi.nlm.nih.gov/pubmed/27855689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0754-9
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