Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation

BACKGROUND: Tolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate the exact mechanisms and efficient treatment. Microglial activation and neuroinflammation in the spinal cord are thought to play pivotal roles on the genesis and maintaining...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neuroinflammation
Prif Awduron: Pan, Yinbing, Sun, Xiaodi, Jiang, Lai, Hu, Liang, Kong, Hong, Han, Yuan, Qian, Cheng, Song, Chao, Qian, Yanning, Liu, Wentao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114746/
https://ncbi.nlm.nih.gov/pubmed/27855689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0754-9
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