Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation

BACKGROUND: Tolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate the exact mechanisms and efficient treatment. Microglial activation and neuroinflammation in the spinal cord are thought to play pivotal roles on the genesis and maintaining...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Pan, Yinbing, Sun, Xiaodi, Jiang, Lai, Hu, Liang, Kong, Hong, Han, Yuan, Qian, Cheng, Song, Chao, Qian, Yanning, Liu, Wentao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114746/
https://ncbi.nlm.nih.gov/pubmed/27855689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0754-9
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