Enhancer of Zeste Homolog 2 Inhibition Stimulates Bone Formation and Mitigates Bone Loss Caused by Ovariectomy in Skeletally Mature Mice

Perturbations in skeletal development and bone degeneration may result in reduced bone mass and quality, leading to greater fracture risk. Bone loss is mitigated by bone protective therapies, but there is a clinical need for new bone-anabolic agents. Previous work has demonstrated that Ezh2 (enhance...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Dudakovic, Amel, Camilleri, Emily T., Riester, Scott M., Paradise, Christopher R., Gluscevic, Martina, O'Toole, Thomas M., Thaler, Roman, Evans, Jared M., Yan, Huihuang, Subramaniam, Malayannan, Hawse, John R., Stein, Gary S., Montecino, Martin A., McGee-Lawrence, Meghan E., Westendorf, Jennifer J., van Wijnen, Andre J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114411/
https://ncbi.nlm.nih.gov/pubmed/27758858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740571
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