Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice

Epigenetic mechanisms control skeletal development and osteoblast differentiation. Pharmacological inhibition of the histone 3 Lys-27 (H3K27) methyltransferase enhancer of zeste homolog 2 (EZH2) in WT mice enhances osteogenesis and stimulates bone formation. However, conditional genetic loss of Ezh2...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Dudakovic, Amel, Camilleri, Emily T., Paradise, Christopher R., Samsonraj, Rebekah M., Gluscevic, Martina, Paggi, Carlo Alberto, Begun, Dana L., Khani, Farzaneh, Pichurin, Oksana, Ahmed, Farah S., Elsayed, Ranya, Elsalanty, Mohammed, McGee-Lawrence, Meghan E., Karperien, Marcel, Riester, Scott M., Thaler, Roman, Westendorf, Jennifer J., van Wijnen, Andre J.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102149/
https://ncbi.nlm.nih.gov/pubmed/29899112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002983
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