Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

Ezh2 is a histone methyltransferase that suppresses osteoblast maturation and skeletal development. We evaluated the role of Ezh2 in chondrocyte lineage differentiation and endochondral ossification. Ezh2 was genetically inactivated in the mesenchymal, osteoblastic, and chondrocytic lineages in mice...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Camilleri, Emily T., Dudakovic, Amel, Riester, Scott M., Galeano-Garces, Catalina, Paradise, Christopher R., Bradley, Elizabeth W., McGee-Lawrence, Meghan E., Im, Hee-Jeong, Karperien, Marcel, Krych, Aaron J., Westendorf, Jennifer J., Larson, A. Noelle, van Wijnen, Andre J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295726/
https://ncbi.nlm.nih.gov/pubmed/30327434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003909
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