Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

Ezh2 is a histone methyltransferase that suppresses osteoblast maturation and skeletal development. We evaluated the role of Ezh2 in chondrocyte lineage differentiation and endochondral ossification. Ezh2 was genetically inactivated in the mesenchymal, osteoblastic, and chondrocytic lineages in mice...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Camilleri, Emily T., Dudakovic, Amel, Riester, Scott M., Galeano-Garces, Catalina, Paradise, Christopher R., Bradley, Elizabeth W., McGee-Lawrence, Meghan E., Im, Hee-Jeong, Karperien, Marcel, Krych, Aaron J., Westendorf, Jennifer J., Larson, A. Noelle, van Wijnen, Andre J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295726/
https://ncbi.nlm.nih.gov/pubmed/30327434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003909
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