Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

Ezh2 is a histone methyltransferase that suppresses osteoblast maturation and skeletal development. We evaluated the role of Ezh2 in chondrocyte lineage differentiation and endochondral ossification. Ezh2 was genetically inactivated in the mesenchymal, osteoblastic, and chondrocytic lineages in mice...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Camilleri, Emily T., Dudakovic, Amel, Riester, Scott M., Galeano-Garces, Catalina, Paradise, Christopher R., Bradley, Elizabeth W., McGee-Lawrence, Meghan E., Im, Hee-Jeong, Karperien, Marcel, Krych, Aaron J., Westendorf, Jennifer J., Larson, A. Noelle, van Wijnen, Andre J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2018
Pynciau:
Gene Regulation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295726/
https://ncbi.nlm.nih.gov/pubmed/30327434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003909
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