Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2

Bone-stimulatory therapeutics include bone morphogenetic proteins (e.g. BMP2), parathyroid hormone, and antibody-based suppression of WNT antagonists. Inhibition of the epigenetic enzyme enhancer of zeste homolog 2 (EZH2) is both bone anabolic and osteoprotective. EZH2 inhibition stimulates key comp...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Dudakovic, Amel, Samsonraj, Rebekah M., Paradise, Christopher R., Galeano-Garces, Catalina, Mol, Merel O., Galeano-Garces, Daniela, Zan, Pengfei, Galvan, M. Lizeth, Hevesi, Mario, Pichurin, Oksana, Thaler, Roman, Begun, Dana L., Kloen, Peter, Karperien, Marcel, Larson, A. Noelle, Westendorf, Jennifer J., Cool, Simon M., van Wijnen, Andre J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2020
Onderwerpen:
Gene Regulation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278362/
https://ncbi.nlm.nih.gov/pubmed/32332097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011685
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