Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex

Proteins are often engineered to have higher affinity for their ligands to achieve therapeutic benefit. For example, many studies have used phage or yeast display libraries of mutants within complementarity-determining regions to affinity mature antibodies and T cell receptors (TCRs). However, these...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Harris, Daniel T., Wang, Ningyan, Riley, Timothy P., Anderson, Scott D., Singh, Nishant K., Procko, Erik, Baker, Brian M., Kranz, David M.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2016
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114409/
https://ncbi.nlm.nih.gov/pubmed/27681597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748681
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