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How a T Cell Receptor-like Antibody Recognizes Major Histocompatibility Complex-bound Peptide

We determined the crystal structures of the T cell receptor (TCR)-like antibody 25-D1.16 Fab fragment bound to a complex of SIINFEKL peptide from ovalbumin and the H-2K(b) molecule. Remarkably, this antibody directly “reads” the structure of the major histocompatibility complex (MHC)-bound peptide,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mareeva, Tatiana, Martinez-Hackert, Erik, Sykulev, Yuri
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570882/
https://ncbi.nlm.nih.gov/pubmed/18703505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804996200
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