Human Major Histocompatibility Complex (MHC) Class I Molecules with Disulfide Traps Secure Disease-related Antigenic Peptides and Exclude Competitor Peptides

The ongoing discovery of disease-associated epitopes detected by CD8 T cells greatly facilitates peptide-based vaccine approaches and the construction of multimeric soluble recombinant proteins (e.g. tetramers) for isolation and enumeration of antigen-specific CD8 T cells. Related to these outcomes...

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Detalhes bibliográficos
Main Authors: Truscott, Steven M., Wang, Xiaoli, Lybarger, Lonnie, Biddison, William E., McBerry, Cortez, Martinko, John M., Connolly, Janet M., Linette, Gerald P., Fremont, Daved H., Hansen, Ted H., Carreno, Beatriz M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276332/
https://ncbi.nlm.nih.gov/pubmed/18195006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709935200
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