Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex

Proteins are often engineered to have higher affinity for their ligands to achieve therapeutic benefit. For example, many studies have used phage or yeast display libraries of mutants within complementarity-determining regions to affinity mature antibodies and T cell receptors (TCRs). However, these...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Harris, Daniel T., Wang, Ningyan, Riley, Timothy P., Anderson, Scott D., Singh, Nishant K., Procko, Erik, Baker, Brian M., Kranz, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114409/
https://ncbi.nlm.nih.gov/pubmed/27681597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748681
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