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Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport

In the retina, aberrant opsin transport from cell bodies to outer segments leads to retinal degenerative diseases such as retinitis pigmentosa. Opsin transport is facilitated by the intraflagellar transport (IFT) system that mediates the bidirectional movement of proteins within cilia. In contrast t...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Boubakri, Meriam, Chaya, Taro, Hirata, Hiromi, Kajimura, Naoko, Kuwahara, Ryusuke, Ueno, Akiko, Malicki, Jarema, Furukawa, Takahisa, Omori, Yoshihiro
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114401/
https://ncbi.nlm.nih.gov/pubmed/27681595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738658
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