Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport

In the retina, aberrant opsin transport from cell bodies to outer segments leads to retinal degenerative diseases such as retinitis pigmentosa. Opsin transport is facilitated by the intraflagellar transport (IFT) system that mediates the bidirectional movement of proteins within cilia. In contrast t...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Boubakri, Meriam, Chaya, Taro, Hirata, Hiromi, Kajimura, Naoko, Kuwahara, Ryusuke, Ueno, Akiko, Malicki, Jarema, Furukawa, Takahisa, Omori, Yoshihiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114401/
https://ncbi.nlm.nih.gov/pubmed/27681595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738658
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