Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport

In the retina, aberrant opsin transport from cell bodies to outer segments leads to retinal degenerative diseases such as retinitis pigmentosa. Opsin transport is facilitated by the intraflagellar transport (IFT) system that mediates the bidirectional movement of proteins within cilia. In contrast t...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Boubakri, Meriam, Chaya, Taro, Hirata, Hiromi, Kajimura, Naoko, Kuwahara, Ryusuke, Ueno, Akiko, Malicki, Jarema, Furukawa, Takahisa, Omori, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114401/
https://ncbi.nlm.nih.gov/pubmed/27681595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738658
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