Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport

In the retina, aberrant opsin transport from cell bodies to outer segments leads to retinal degenerative diseases such as retinitis pigmentosa. Opsin transport is facilitated by the intraflagellar transport (IFT) system that mediates the bidirectional movement of proteins within cilia. In contrast t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Boubakri, Meriam, Chaya, Taro, Hirata, Hiromi, Kajimura, Naoko, Kuwahara, Ryusuke, Ueno, Akiko, Malicki, Jarema, Furukawa, Takahisa, Omori, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114401/
https://ncbi.nlm.nih.gov/pubmed/27681595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738658
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