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Human translesion polymerase kappa exhibits enhanced activity and reduced fidelity two nucleotides from G-quadruplex DNA
We have investigated the in vitro properties of human Y-family polymerase kappa (hpol κ) on G-quadruplex DNA (G4 DNA). Similar to hpol η, another Y-family member implicated in replication of G4 motifs, hpol κ bound G4 DNA with a 5.7-fold preference over control, non-G4 DNA. Results from pol extensio...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5113810/ https://ncbi.nlm.nih.gov/pubmed/27525498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00374 |
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