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Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms

Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors. We previously reported on the development and cha...

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書目詳細資料
發表在:ACS Chem Biol
Main Authors: Ketkar, Amit, Maddukuri, Leena, Penthala, Narsimha R., Reed, Megan R., Zafar, Maroof K., Crooks, Peter A., Eoff, Robert L.
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357868/
https://ncbi.nlm.nih.gov/pubmed/31082191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00304
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