Mirror‐Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide

Programs of drug discovery generally exploit one enantiomer of a chiral compound for lead development following the principle that enantiomer recognition is central to biological specificity. However, chiral promiscuity has been identified for a number of enzyme families, which have shown that mirro...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Autores principales: Bisson, Claudine, Britton, K. Linda, Sedelnikova, Svetlana E., Rodgers, H. Fiona, Eadsforth, Thomas C., Viner, Russell C., Hawkes, Tim R., Baker, Patrick J., Rice, David W.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113775/
https://ncbi.nlm.nih.gov/pubmed/27717128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201607185
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