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Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM
Histidine biosynthesis is an essential process in plants and microorganisms, making it an attractive target for the development of herbicides and antibacterial agents. Imidazoleglycerol-phosphate dehydratase (IGPD), a key enzyme within this pathway, has been biochemically characterized in both Sacch...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5828572/ https://ncbi.nlm.nih.gov/pubmed/29434040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708839115 |
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