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HF‐Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization
We have developed a convenient method for the direct synthesis of peptide thioesters, versatile intermediates for peptide ligation and cyclic peptide synthesis. The technology uses a modified Boc SPPS strategy that avoids the use of anhydrous HF. Boc in situ neutralization protocols are used in comb...
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| 出版年: | Angew Chem Int Ed Engl |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5113665/ https://ncbi.nlm.nih.gov/pubmed/27654901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201607657 |
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