HF‐Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

We have developed a convenient method for the direct synthesis of peptide thioesters, versatile intermediates for peptide ligation and cyclic peptide synthesis. The technology uses a modified Boc SPPS strategy that avoids the use of anhydrous HF. Boc in situ neutralization protocols are used in comb...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Raz, Richard, Burlina, Fabienne, Ismail, Mohamed, Downward, Julian, Li, Jiejin, Smerdon, Stephen J., Quibell, Martin, White, Peter D., Offer, John
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113665/
https://ncbi.nlm.nih.gov/pubmed/27654901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201607657
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