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Spontaneous head-to-tail cyclization of unprotected linear peptides with the KAHA ligation
The α-ketoacid–hydroxylamine (KAHA) ligation with 5-oxaproline enables the direct cyclization of peptides upon cleavage from a solid support, without coupling reagents, protecting groups, or purification of the linear precursors. This Fmoc SPPS-based method was applied to the synthesis of a library...
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| Publié dans: | Chem Sci |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Royal Society of Chemistry
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5664356/ https://ncbi.nlm.nih.gov/pubmed/29142720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01774b |
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