Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins

Target deconvolution is one of the most challenging tasks in drug discovery, but a key step in drug development. In contrast to small molecules, there is a lack of validated and robust methodologies for target elucidation of peptides. In particular, it is difficult to apply these methods to cyclic a...

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Bibliografiska uppgifter
I publikationen:Front Chem
Huvudupphovsmän: Hellinger, Roland, Thell, Kathrin, Vasileva, Mina, Muhammad, Taj, Gunasekera, Sunithi, Kümmel, Daniel, Göransson, Ulf, Becker, Christian W., Gruber, Christian W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2017
Ämnen:
Chemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641551/
https://ncbi.nlm.nih.gov/pubmed/29075625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2017.00073
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