Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing

The complement system is proposed to play an important role in the pathogenesis of rheumatoid arthritis (RA). The complement system mannan-binding lectin associated serine proteases 1 and 3 (MASP-1/3) cleave proDf (inactive) into Df (active), but it is unknown where this cleavage occurs and whether...

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Vydáno v:J Immunol
Hlavní autoři: Banda, Nirmal K., Acharya, Sumitra, Scheinman, Robert I., Mehta, Gaurav, Coulombe, Marilyne, Takahashi, Minoru, Sekine, Hideharu, Thiel, Steffen, Fujita, Teizo, Holers, V Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113144/
https://ncbi.nlm.nih.gov/pubmed/27707997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600719
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