Targeting of Liver Mannan-Binding Lectin–Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis

Mannan-binding lectin–associated serine protease 3 (MASP-3) regulates the alternative pathway of complement and is predominantly synthesized in the liver. The role of liver-derived MASP-3 in the pathogenesis of rheumatoid arthritis (RA) is unknown. We hypothesized that liver-derived MASP-3 is essent...

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Detalhes bibliográficos
Publicado no:Immunohorizons
Main Authors: Banda, Nirmal K., Desai, Dhruv, Scheinman, Robert I., Pihl, Rasmus, Sekine, Hideharu, Fujita, Teizo, Sharma, Vibha, Hansen, Annette G., Garred, Peter, Thiel, Steffen, Borodovsky, Anna, Holers, V. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220895/
https://ncbi.nlm.nih.gov/pubmed/30417171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.1800053
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