Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D

The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the alternative pathway (AP). We evaluated the effect...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Holers, V. Michael, Borodovsky, Anna, Scheinman, Robert I., Ho, Nhu, Ramirez, Joseline Ramos, Dobó, József, Gál, Péter, Lindenberger, Jared, Hansen, Annette G., Desai, Dhruv, Pihl, Rasmus, Thiel, Steffen, Banda, Nirmal K.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046807/
https://ncbi.nlm.nih.gov/pubmed/32153567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00201
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