Targeting Mll1 H3K4 methyltransferase activity to guide cardiac lineage specific reprogramming of fibroblasts

Generation of induced cardiomyocytes (iCMs) directly from fibroblasts offers a great opportunity for cardiac disease modeling and cardiac regeneration. A major challenge of iCM generation is the low conversion rate. To address this issue, we attempted to identify small molecules that could potentiat...

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Vydáno v:Cell Discov
Hlavní autoři: Liu, Liu, Lei, Ienglam, Karatas, Hacer, Li, Yangbing, Wang, Li, Gnatovskiy, Leonid, Dou, Yali, Wang, Shaomeng, Qian, Li, Wang, Zhong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113048/
https://ncbi.nlm.nih.gov/pubmed/27924221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.36
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