Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)(n) Repeats by PNA or LNA Targeting

Expansion of (GAA)(n) repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich’s ataxia. (GAA)(n) expansions form non-canonical structures, including intramolecular triplex (H-DNA), and R-loops and are associated with epige...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Bergquist, Helen, Rocha, Cristina S. J., Álvarez-Asencio, Rubén, Nguyen, Chi-Hung, Rutland, Mark. W., Smith, C. I. Edvard, Good, Liam, Nielsen, Peter E., Zain, Rula
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112992/
https://ncbi.nlm.nih.gov/pubmed/27846236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165788
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