Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)(n) Repeats by PNA or LNA Targeting

Expansion of (GAA)(n) repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich’s ataxia. (GAA)(n) expansions form non-canonical structures, including intramolecular triplex (H-DNA), and R-loops and are associated with epige...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bergquist, Helen, Rocha, Cristina S. J., Álvarez-Asencio, Rubén, Nguyen, Chi-Hung, Rutland, Mark. W., Smith, C. I. Edvard, Good, Liam, Nielsen, Peter E., Zain, Rula
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5112992/
https://ncbi.nlm.nih.gov/pubmed/27846236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165788
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