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Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species

Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase that functions as metabolic sensor of cellular energy and modulates biochemical pathways in the adaptation to changes in the environment. SIRT1 substrates include histones and proteins related to enhancement of mitochondrial function as well as an...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Aguilar-Arnal, Lorena, Ranjit, Suman, Stringari, Chiara, Orozco-Solis, Ricardo, Gratton, Enrico, Sassone-Corsi, Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111721/
https://ncbi.nlm.nih.gov/pubmed/27791113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609227113
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