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NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
The circadian clock controls the transcription of hundred genes through specific chromatin remodeling events. The histone methyltransferase Mixed-Lineage Leukemia 1 (MLL1) coordinates recruitment of CLOCK–BMAL1 activator complexes to chromatin, an event associated to cyclic H3K4 tri-methylation at c...
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| Gepubliceerd in: | Nat Struct Mol Biol |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4732879/ https://ncbi.nlm.nih.gov/pubmed/25751424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2990 |
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