Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance indicates that estrogen plays a critical role in LA...

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Publicado en:JCI Insight
Main Authors: Li, Chenggang, Li, Na, Liu, Xiaolei, Zhang, Erik Y., Sun, Yang, Masuda, Kouhei, Li, Jing, Sun, Julia, Morrison, Tasha, Li, Xiangke, Chen, Yuanguang, Wang, Jiang, Karim, Nagla A., Zhang, Yi, Blenis, John, Reginato, Mauricio J., Henske, Elizabeth P., Yu, Jane J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111508/
https://ncbi.nlm.nih.gov/pubmed/27882343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86629
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