Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance indicates that estrogen plays a critical role in LA...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Li, Chenggang, Li, Na, Liu, Xiaolei, Zhang, Erik Y., Sun, Yang, Masuda, Kouhei, Li, Jing, Sun, Julia, Morrison, Tasha, Li, Xiangke, Chen, Yuanguang, Wang, Jiang, Karim, Nagla A., Zhang, Yi, Blenis, John, Reginato, Mauricio J., Henske, Elizabeth P., Yu, Jane J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111508/
https://ncbi.nlm.nih.gov/pubmed/27882343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86629
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