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Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance indicates that estrogen plays a critical role in LA...
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Publicado no: | JCI Insight |
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Main Authors: | , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5111508/ https://ncbi.nlm.nih.gov/pubmed/27882343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86629 |
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