Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance indicates that estrogen plays a critical role in LA...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Li, Chenggang, Li, Na, Liu, Xiaolei, Zhang, Erik Y., Sun, Yang, Masuda, Kouhei, Li, Jing, Sun, Julia, Morrison, Tasha, Li, Xiangke, Chen, Yuanguang, Wang, Jiang, Karim, Nagla A., Zhang, Yi, Blenis, John, Reginato, Mauricio J., Henske, Elizabeth P., Yu, Jane J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111508/
https://ncbi.nlm.nih.gov/pubmed/27882343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86629
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