Faslodex Inhibits Estradiol-Induced Extracellular Matrix Dynamics and Lung Metastasis in a Model of Lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a destructive lung disease primarily affecting women. Genetic studies indicate that LAM cells carry inactivating tuberous sclerosis complex (TSC)–2 mutations, and metastasize to the lung. We previously discovered that estradiol increases the metastasis of TSC2-defic...

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Main Authors: Li, Chenggang, Zhou, Xiaobo, Sun, Yang, Zhang, Erik, Mancini, John D., Parkhitko, Andrey, Morrison, Tasha A., Silverman, Edwin K., Henske, Elizabeth P., Yu, Jane J.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727883/
https://ncbi.nlm.nih.gov/pubmed/23526212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0476OC
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