Faslodex Inhibits Estradiol-Induced Extracellular Matrix Dynamics and Lung Metastasis in a Model of Lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a destructive lung disease primarily affecting women. Genetic studies indicate that LAM cells carry inactivating tuberous sclerosis complex (TSC)–2 mutations, and metastasize to the lung. We previously discovered that estradiol increases the metastasis of TSC2-defic...

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Detalhes bibliográficos
Main Authors: Li, Chenggang, Zhou, Xiaobo, Sun, Yang, Zhang, Erik, Mancini, John D., Parkhitko, Andrey, Morrison, Tasha A., Silverman, Edwin K., Henske, Elizabeth P., Yu, Jane J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727883/
https://ncbi.nlm.nih.gov/pubmed/23526212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0476OC
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