Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity

Obesity is associated with increased classically activated M1 adipose tissue macrophages (ATMs) and decreased alternatively activated M2 ATMs, both of which contribute to obesity-induced inflammation and insulin resistance. However, the underlying mechanism remains unclear. We find that inhibiting D...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Wang, Xianfeng, Cao, Qiang, Yu, Liqing, Shi, Huidong, Xue, Bingzhong, Shi, Hang
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111504/
https://ncbi.nlm.nih.gov/pubmed/27882346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87748
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