Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism

Cullin-3 (CUL3) mutations (CUL3Δ9) were previously identified in hypertensive patients with pseudohypoaldosteronism type-II (PHAII), but the mechanism causing hypertension and whether this is driven by renal tubular or extratubular mechanisms remains unknown. We report that selective expression of C...

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Pubblicato in:JCI Insight
Autori principali: Agbor, Larry N., Ibeawuchi, Stella-Rita C., Hu, Chunyan, Wu, Jing, Davis, Deborah R., Keen, Henry L., Quelle, Frederick W., Sigmund, Curt D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111503/
https://ncbi.nlm.nih.gov/pubmed/27882355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91015
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