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Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E

There is a growing body of evidence that the nondegradable fluorophores that accumulate as the lipofuscin of retinal pigment epithelium (RPE) are involved in mechanisms leading to the degeneration of RPE in macular degeneration. Most of the constituents of RPE lipofuscin are inadvertent products of...

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Detalhes bibliográficos
Main Authors: Kim, So Ra, Fishkin, Nathan, Kong, Jian, Nakanishi, Koji, Allikmets, Rando, Sparrow, Janet R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC511036/
https://ncbi.nlm.nih.gov/pubmed/15277666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403499101
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