Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis

PURPOSE: Oxidative stress, partly due to light, has an important role in many retinal diseases, including macular degeneration and retinal dystrophies. The Leu450Met variant of RPE65 is expressed in C57BL/6 and in many genetically modified mice. It confers significant resistance to light induced ret...

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Bibliographische Detailangaben
Veröffentlicht in:Invest Ophthalmol Vis Sci
Hauptverfasser: Zhong, Xin, Aredo, Bogale, Ding, Yi, Zhang, Kaiyan, Zhao, Cynthia X., Ufret-Vincenty, Rafael L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2016
Schlagworte:
Retina
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080935/
https://ncbi.nlm.nih.gov/pubmed/27768794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19965
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