A Chimeric Cfh Transgene Leads to Increased Retinal Oxidative Stress, Inflammation, and Accumulation of Activated Subretinal Microglia in Mice

PURPOSE. Variants of complement factor H (Cfh) affecting short consensus repeats (SCRs) 6 to 8 increase the risk of age-related macular degeneration. Our aim was to explore the effect of expressing a Cfh variant on the in vivo susceptibility of the retina and RPE to oxidative stress and inflammation...

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Bibliografische gegevens
Gepubliceerd in:Invest Ophthalmol Vis Sci
Hoofdauteurs: Aredo, Bogale, Li, Tao, Chen, Xiao, Zhang, Kaiyan, Wang, Cynthia Xin-Zhao, Gou, Darlene, Zhao, Biren, He, Yuguang, Ufret-Vincenty, Rafael L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Association for Research in Vision and Ophthalmology 2015
Onderwerpen:
Retina
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464010/
https://ncbi.nlm.nih.gov/pubmed/26030099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-16089
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