A Chimeric Cfh Transgene Leads to Increased Retinal Oxidative Stress, Inflammation, and Accumulation of Activated Subretinal Microglia in Mice

PURPOSE. Variants of complement factor H (Cfh) affecting short consensus repeats (SCRs) 6 to 8 increase the risk of age-related macular degeneration. Our aim was to explore the effect of expressing a Cfh variant on the in vivo susceptibility of the retina and RPE to oxidative stress and inflammation...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Invest Ophthalmol Vis Sci
Κύριοι συγγραφείς: Aredo, Bogale, Li, Tao, Chen, Xiao, Zhang, Kaiyan, Wang, Cynthia Xin-Zhao, Gou, Darlene, Zhao, Biren, He, Yuguang, Ufret-Vincenty, Rafael L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Association for Research in Vision and Ophthalmology 2015
Θέματα:
Retina
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4464010/
https://ncbi.nlm.nih.gov/pubmed/26030099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-16089
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια