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Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E

There is a growing body of evidence that the nondegradable fluorophores that accumulate as the lipofuscin of retinal pigment epithelium (RPE) are involved in mechanisms leading to the degeneration of RPE in macular degeneration. Most of the constituents of RPE lipofuscin are inadvertent products of...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Kim, So Ra, Fishkin, Nathan, Kong, Jian, Nakanishi, Koji, Allikmets, Rando, Sparrow, Janet R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC511036/
https://ncbi.nlm.nih.gov/pubmed/15277666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403499101
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