Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury

The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 (CXCR1) and CXCR2. Here we characterize the unique mode of action of a small-molecule inhibitor (Repertaxin) of CXCR1 and CXCR2. Structural and biochemica...

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מידע ביבליוגרפי
Main Authors: Bertini, Riccardo, Allegretti, Marcello, Bizzarri, Cinzia, Moriconi, Alessio, Locati, Massimo, Zampella, Giuseppe, Cervellera, Maria N., Di Cioccio, Vito, Cesta, Maria C., Galliera, Emanuela, Martinez, Fernando O., Di Bitondo, Rosa, Troiani, Giulia, Sabbatini, Vilma, D'Anniballe, Gaetano, Anacardio, Roberto, Cutrin, Juan C., Cavalieri, Barbara, Mainiero, Fabrizio, Strippoli, Raffaele, Villa, Pia, Di Girolamo, Maria, Martin, Franck, Gentile, Marco, Santoni, Angela, Corda, Daniela, Poli, Giuseppe, Mantovani, Alberto, Ghezzi, Pietro, Colotta, Francesco
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2004
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC511013/
https://ncbi.nlm.nih.gov/pubmed/15282370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402090101
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