Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor

BACKGROUND AND PURPOSE: DF 2156A is a new dual inhibitor of IL-8 receptors CXCR1 and CXCR2 with an optimal pharmacokinetic profile. We characterized its binding mode, molecular mechanism of action and selectivity, and evaluated its therapeutic potential. EXPERIMENTAL APPROACH: The binding mode, mole...

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Bibliografiska uppgifter
Huvudupphovsmän: Bertini, R, Barcelos, LS, Beccari, AR, Cavalieri, B, Moriconi, A, Bizzarri, C, Di Benedetto, P, Di Giacinto, C, Gloaguen, I, Galliera, E, Corsi, MM, Russo, RC, Andrade, SP, Cesta, MC, Nano, G, Aramini, A, Cutrin, JC, Locati, M, Allegretti, M, Teixeira, MM
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2012
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268197/
https://ncbi.nlm.nih.gov/pubmed/21718305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01566.x
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