Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats

BACKGROUND AND PURPOSE: Chemokine receptors CXCR1 and CXCR2 may mediate influx of neutrophils in models of acute and chronic inflammation. The potential benefits of oral administration of a CXCR1/2 inhibitor, DF 2162, in adjuvant-induced polyarthritis (AIA) were investigated. EXPERIMENTAL APPROACH:...

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Autores principales: Barsante, M M, Cunha, T M, Allegretti, M, Cattani, F, Policani, F, Bizzarri, C, Tafuri, W L, Poole, S, Cunha, F Q, Bertini, R, Teixeira, M M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267272/
https://ncbi.nlm.nih.gov/pubmed/17891165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707462
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