Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury

The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 (CXCR1) and CXCR2. Here we characterize the unique mode of action of a small-molecule inhibitor (Repertaxin) of CXCR1 and CXCR2. Structural and biochemica...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Bertini, Riccardo, Allegretti, Marcello, Bizzarri, Cinzia, Moriconi, Alessio, Locati, Massimo, Zampella, Giuseppe, Cervellera, Maria N., Di Cioccio, Vito, Cesta, Maria C., Galliera, Emanuela, Martinez, Fernando O., Di Bitondo, Rosa, Troiani, Giulia, Sabbatini, Vilma, D'Anniballe, Gaetano, Anacardio, Roberto, Cutrin, Juan C., Cavalieri, Barbara, Mainiero, Fabrizio, Strippoli, Raffaele, Villa, Pia, Di Girolamo, Maria, Martin, Franck, Gentile, Marco, Santoni, Angela, Corda, Daniela, Poli, Giuseppe, Mantovani, Alberto, Ghezzi, Pietro, Colotta, Francesco
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2004
الموضوعات:
Biological Sciences
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC511013/
https://ncbi.nlm.nih.gov/pubmed/15282370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402090101
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