Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2

[Image: see text] The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure–act...

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Detalhes bibliográficos
Principais autores: Maeda, Dean Y., Peck, Angela M., Schuler, Aaron D., Quinn, Mark T., Kirpotina, Liliya N., Wicomb, Winston N., Fan, Guo-Huang, Zebala, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207547/
https://ncbi.nlm.nih.gov/pubmed/25254640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500827t
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