Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2

[Image: see text] The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure–act...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Maeda, Dean Y., Peck, Angela M., Schuler, Aaron D., Quinn, Mark T., Kirpotina, Liliya N., Wicomb, Winston N., Fan, Guo-Huang, Zebala, John A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2014
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207547/
https://ncbi.nlm.nih.gov/pubmed/25254640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500827t
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