Boronic acid-containing CXCR1/2 antagonists: optimization of metabolic stability, in vivo evaluation, and a proposed receptor binding model

Blockade of undesired neutrophil migration to sites of inflammation remains an area of substantial pharmaceutical interest. To effect this blockade, a validated therapeutic target is antagonism of the chemokine receptor CXCR2. Herein we report the discovery of 6-(2-boronic acid-5-trifluoromethoxy-be...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Maeda, Dean Y., Peck, Angela M., Schuler, Aaron D., Quinn, Mark T., Kirpotina, Liliya N., Wicomb, Winston N., Auten, Richard L., Gundla, Rambabu, Zebala, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430358/
https://ncbi.nlm.nih.gov/pubmed/25933594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.041
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