Boronic Acid-Containing Aminopyridine- and Aminopyrimidinecarboxamide CXCR1/2 Antagonists: Optimization of Aqueous Solubility and Oral Bioavailability

The chemokine receptors CXCR1 and CXCR2 are important pharmaceutical targets due to their key roles in inflammatory diseases and cancer progression. We have previously identified 2-[5-(4-Fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanylmethyl]-phenylboronic acid (SX-517) and 6-(2-boronic acid-5-trifluoro...

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Publicado no:Bioorg Med Chem Lett
Main Authors: Schuler, Aaron D., Engles, Courtney A., Maeda, Dean Y., Quinn, Mark T., Kirpotina, Liliya N., Wicomb, Winston N., Mason, S. Nicholas, Auten, Richard L., Zebala, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564001/
https://ncbi.nlm.nih.gov/pubmed/26248802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.07.090
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