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Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability

Overproduction of nitric oxide by neuronal nitric oxide synthase (nNOS) has been linked to several neurodegenerative diseases. We have recently designed potent and isoform selective inhibitors of nNOS, but the lead compound contains several basic functional groups. A large number of charges and hydr...

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Detaylı Bibliyografya
Asıl Yazarlar: Lawton, Graham R., Ranaivo, Hantamalala Ralay, Chico, Laura K., Ji, Haitao, Xue, Fengtian, Martásek, Pavel, Roman, Linda J., Watterson, D. Martin, Silverman, Richard B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775099/
https://ncbi.nlm.nih.gov/pubmed/19268602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.02.017
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