Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability

Overproduction of nitric oxide by neuronal nitric oxide synthase (nNOS) has been linked to several neurodegenerative diseases. We have recently designed potent and isoform selective inhibitors of nNOS, but the lead compound contains several basic functional groups. A large number of charges and hydr...

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Detalhes bibliográficos
Main Authors: Lawton, Graham R., Ranaivo, Hantamalala Ralay, Chico, Laura K., Ji, Haitao, Xue, Fengtian, Martásek, Pavel, Roman, Linda J., Watterson, D. Martin, Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775099/
https://ncbi.nlm.nih.gov/pubmed/19268602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.02.017
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